Fig. 3From: Inhibition of ZDHHC16 promoted osteogenic differentiation and reduced ferroptosis of dental pulp stem cells by CREBThe inhibition of ZDHHC16 reduced Ferroptosis of DPSCsGPX4 protein expression (A1, A2), GSH activity (C), MPT (calcein AM/CoCl2 assay, G), JC-1 disaggregation (H) were inhibited by up-regulation of ZDHHC16, and iron concentration (D), LDH activity level (E), PI positive cells (F) were increased by up-regulation of ZDHHC16; GPX4 protein expression (B1, B2), GSH activity (C), MPT (calcein AM/CoCl2 assay, G), JC-1 disaggregation (H) were increased by down-regulation of ZDHHC16, and iron concentration (D), LDH activity level (E), PI positive cells (F) were decreased by down-regulation of ZDHHC16.**p < 0.01 compared with negative or si-nc.Back to article page