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Table 5 GSTs genotype frequencies in periodontitis patients and controls according to their smoking status♦

From: Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study

Genotypes

Non-smoking controls

(N = 129)

Non-smoking periodontitis patients

(N = 130)

p level

OR (95%CI)

Smoking controls

(N = 58)

Smoking periodontitis patients (N = 57)

p level

OR (95%CI)

GSTM1

 

Wild

59 (45.7)

63 (48.5)

0.38

1.00

31 (53.4)

25 (43.9)

0.20

1.00

Null

70 (54.3)

67 (51.5)

0.90 (0.55–1.46)

27 (46.6)

32 (56.1)

1.47 (0.70–3.06)

GSTT1

 

Wild

96 (74.4)

110 (84.6)

0.03*

1.00

48 (82.8)

43 (75.4)

0.23

1.00

Null

33 (25.6)

20 (15.4)

0.53 (0.28–0.98)

10 (17.2)

14 (24.6)

1.56 (0.63–3.88)

GSTM1/GSTT1

 

Both wild

44 (34.1)

50 (38.5)

0.07

1.00

24 (41.4)

21 (36.8)

0.11

1.00

Either null

67 (51.9)

73 (56.2)

1.04 (0.62–1.76)

31 (53.4)

26 (45.6)

0.96 (0.44–2.10)

Both null

18 (14.0)

7 (5.4)

0.34 (0.13–0.90)

3 (5.2)

10 (17.5)

3.81 (0.92–15.71)

GSTP1 Ile105Val

(rs1695 A313G)

 

AA (Ile/Ile)

38 (43.7)

72 (55.8)

0.14

1.00

32 (66.7)

30 (53.6)

0.35

1.00

AG (Ile/Val)

42 (48.3)

45 (34.9)

0.57 (0.32–1.01)

14 (29.2)

24 (42.9)

1.83 (0.80–4.18)

GG (Val/Val)

7 (8.0)

12 (9.3)

1.11 (0.40–3.04)

2 (4.2)

2 (3.6)

0.94 (0.12–7.08)

GSTP1 Ala114Val

(rs1138272 C341T)

 

CC (Ala/Ala)

69 (79.3)

113 (87.6)

0.009*

1.00

44 (91.7)

50 (89.3)

0.68

1.00

CT (Ala/Val)

18 (20.7)

11 (8.5)

0.37 (0.17–0.84)

4 (8.3)

6 (10.7)

1.32 (0.35–4.98)

TT (Val/Val)

0 (0.0)

5 (3.9)

NA

0 (0.0)

0 (0.0)

NA

GSTP1

 

*A/*A

38 (43.7)

72 (55.8)

0.04*

1.00

32 (66.7)

30 (53.6)

0.54

1.00

*A/*B

29 (33.3)

36 (27.9)

0.66 (0.35–1.23)

10 (20.8)

18 (32.1)

1.92 (0.77-4:82)

*A/*C

13 (14.9)

9 (7.0)

0.37 (0.14–0.93)

4 (8.3)

6 (10.7)

1.60 (0.41–6.23)

*B/*B

2 (2.3)

5 (3.9)

1.32 (0.24–7.12)

2 (4.2)

2 (3.6)

0.94 (0.12–7.08)

*B/*C

5 (5.7)

2 (1.6)

0.21 (0.04–1.14)

0 (0.0)

0 (0.0)

NA

*C/*C

0 (0.0)

5 (3.9)

NA

0 (0.0)

0 (0.0)

NA

  1. ♦Smoking status was known only in subgroups of periodontitis patients and controls
  2. *pcorr > 0.05