From: The growth factor multimodality on treating human dental mesenchymal stem cells: a systematic review
Literature | GFs | Cell types | Receptors | Pathways | Effects |
---|---|---|---|---|---|
Sun-Yi Hyun et al. [48] | FGF-2, TGF-β1, BMP-2/-4 | PDLSC | - | - | FGF-2 collaborates with TGF-β1 to stimulate fibrotic differentiation and antagonize BMP osteogenic/cemental differentiation |
Nan Xiao et al. [49] | BDNF, NT4/5 | DPSC | TrkB | ERK/MAPK | accelerate migration and wound healing |
Wanyu Lu et al. [50] | IGF-1,VEGF | DPSC | - | AKT | combined to promote proliferative migration and osteogenesis, the effect alone is not obvious |
Kun Xia et al. [51] | RGD, VEGF | DPSC | - | - | promote cell adhesion, angiogenesis, and endodontic regeneration |
Francesco Paduano et al. [52] | Medium (EGF, bFGF) | DPSC | - | - | up-regulate osteogenesis-specific markers |
Anna Di Vito et al. [53] | Medium (EGF, FGF) | PDLSC | - | - | maintain growth and dryness with higher osteogenic potential |
Jingyi Xiao et al. [54] | Medium (FGF2, TGF β1) | DPSC | - | - | higher maintenance of cell proliferation, pluripotency, migration, and stability |
Jialin Chen et al. [55] | Medium (bFGF-2, TGF-β3, SP) | PDLSC | - | - | construction of multilayer human corneal stromal-like tissue |
Wendy Martens et al. [56] | Medium (PDGF-aa, bFGF, NRG) | DPSC | - | - | induce differentiation into Schwann-like cells |
A Longoni et al. [57] | Medium (TGF-β3, BMP-2/-6/-7, IGF-1) | DPSC | - | - | fibrocartilaginous tissue is formed, hyaline cartilage is not formed |
Huong Thi Nguyen Nguyen et al. [58] | Medium (EGF, bFGF, BDNF) | SHED | - | - | induction into neurons improves neurite development and mitochondrial function |
Xu, JG et al. [59] | Medium (TGF-β1, BMP4) | SHED | - | TGF-β1-ALK5 | derived to SMC |
Hua-Lian Cao et al. [60] | AFC | DPSC, PDLSC | - | - | GF source that promotes dentin/dentin differentiation, cell expansion |
Prakan Thanasrisuebwong et al. [61] | i-PRF | PDLSC | - | - | yellow i-PRF stimulates osteogenic differentiation earlier, and red i-PRF is more suitable for bone regeneration |
Melissa Lo Monaco et al. [62] | L-PRF | DPSC | - | - | an immunomodulatory effect, stimulate the survival of chondrocytes |
Ali Sadeghinia et al. [63] | a-PRP | DPSC | - | - | accelerate cell osteogenic differentiation, mineralization, and expression of bone gene markers |
Yunhe Xu et al. [64] | PRP | PDLSC | - | autophagy | concentration-dependent enhancement of cell viability and osteogenic differentiation |
Qiu Xu et al. [65] | PRP | PDLSC | - | - | significantly enhances osteogenesis, with a concentration of 1% being the most effective mode of administration |
Bei-Min Tian et al. [66] | PL | PDLSC | - | - | improve the osteogenic potential and support cell sheet formation |
Gengtao Qiu et al. [67] | PL | PDLSC | Â | Â | enhance osteogenic differentiation potential |
Gengtao Qiu et al. [68] | PL | PDLSC | - | - | improve cell viability and osteogenic differentiation, 2.5% is the optimal concentration |
Nela Pilbauerova et al. [69] | PL | DPSC | - | - | serum substitute for expanded stem cells in vitro |
Hanan Jafar et al. [70] | PL | SCAP, PDLSC | - | - | a suitable substitute for animal-derived serums that contribute to bone |
Tong Lei et al. [71] | PL | SHED | - | - | promote stem cell proliferation and differentiation, and standardize cell production methods |