From: The growth factor multimodality on treating human dental mesenchymal stem cells: a systematic review
Literature | GFs | Cell types | Receptors | Pathways | Effects |
---|---|---|---|---|---|
Chun Fan et al. [17] | TGF-β1 | PDLSC | - | ROS | induce aging |
Hsiao-Hua Chang et al. [18] | TGF-β1 | SHED | TGF-βRI, TGF-βRII | ALK5/Smad2, TAK1, p38, MEK/ERK | promote proliferation, collagen turnover, and differentiation |
Liming Jiang et al. [19] | TGF-β1 | DPSC | - | - | promote pulp regeneration or restorative dentin formation |
Parisa Ghandforoushan et al. [20] | TGF-β1 | DPSC | - | - | promote adhesion, proliferation, and differentiation of chondrocytes |
Alireza Moshaverinia et al. [21] | TGF-β3 | PDLSC, GMSC | - | - | promote tendon repair and regeneration |
Yangfan Li et al. [22] | TGF-β3 | PDLSC | - | - | promote osteogenic differentiation and repair incomplete bone defects |
Jingting Lu et al. [23] | FGF9 | DPSC | - | ERK1/2 | inhibit osteogenic differentiation |
Caroline Gorin et al. [24] | FGF-2 | SHED | - | - | induce the release of VEGF and HGF and enhance the angiogenesis potential |
Anita Novais et al. [25] | FGF-2 | SHED | - | - | increase the bone healing potential |
Chunshu Zhang et al. [26] | FGF-2 | PDLSC | - | - | promote proliferation, dry expression, and cytokine secretion |
Jessica Ratajczak et al. [27] | FGF-2 | PDLSC | - | - | promote angiogenesis secretion |
J Qian et al. [28] | bFGF | DPSC | - | - | treatment for 1Â week to increase bone formation, treatment for 2Â weeks to reduce bone formation |
Lihua Luo et al. [29] | bFGF | DPSC | - | ERK, TRPC1 | save the proliferative activity of frozen cells without changing the dry and pluripotency |
Nunthawan Nowwarote et al. [30] | bFGF | SHED | - | Pi/PPi metabolism | increase the number of cells and maintain stem cell characteristics |
Casiano Del Angel-Mosqueda et al. [31] | EGF | DPSC | - | - | promote extracellular matrix mineralization, osteogenic differentiation |
bFGF | DPSC | - | - | inhibit osteogenic differentiation | |
De-Hua Zheng et al. [32] | EPO | PDLSC | - | Wnt/β-catenin | dose-dependent contributes to bone differentiation |
Liying Wang et al. [33] | EPO | PDLSC | - | p38 MAPK | promote proliferation and osteogenic differentiation |
Ji Hoon Park et al. [34] | BMP peptide | DPSC | - | - | support high cell viability, accelerates proliferation and odontogenic differentiation |
Selen Küçükkaya Eren et al. [35] | BMP-7 | DPSC | - | - | increase osteogenic differentiation and regeneration |
Cheng Liang et al. [36] | BMP7 | DPSC | - | - | promote vascular regeneration in a concentration-dependent manner |
TGF-β1 | DPSC | - | - | completely inhibits calcification, | |
Seung Hun Park et al. [37] | BMP2 | PDLSC | - | - | promote osteogenic differentiation non-invasively |
Edit Hrubi et al. [38] | BMP2 | DPSC | BMPRI, BMPRII | - | inhibit cell proliferation, and use alone is not sufficient to induce osteogenesis |
Joo-Young Park et al. [39] | BMP-2 | PDLSC | - | - | higher mineralization and collagen synthesis |
Qian Zeng et al. [40] | CGF | DPSC | - | - | promote pulp healing |
Joshua N Winderlich et al. [41] | VEGF-a | DPSC | VEGF-R2 | - | increase the permeability of the blood–brain barrier, stimulate the adhesion and migration of cells |
J G Xu et al. [42] | VEGF-a | SHED, DPSC | - | SMAD2/3 | enhance endothelial differentiation |
Nan Xiao et al. [43] | GDNF | DPSC | GFR | AKT, MAPK | increase migration and promote rapid wound healing |
Arwa A Al-Maswary et al. [44] | BDNF | DPSC | - | ERK/MAPK | promote differentiation into typical neuron-like cells |
Saikrishna Kandalam et al. [45] | BDNF | SCAP[55] | - | - | induce immune regulation, protect nerves, and promote the expression of neuronal markers |
Ji-Hyun Kim et al. [46] | BDNF | DPSC | TrkB | - | induce odontogenic differentiation |
Zhenqing Liu et al. [47] | NGF | - | p75NTR | JNK | activation of the DLX5 gene contributes to bone |