Fig. 5
From: CDH4 inhibits ferroptosis in oral squamous cell carcinoma cells
CDH4 can reduce the sensitivity of OSCC cells to ferroptosis. In the representative images, live cells fluoresced green (Calcein/AM) and dead cells fluoresced red (PI) A, C. The images include at least five randomly selected fields of view under a 400X laser confocal microscope. The statistical graph shows the percentage of dead cells B, D. The western blot experiment showed the expression of GPX4 in the CDH4 down-regulation experiment and CDH4 up-regulation experiment E–F. The expression of GSH, GSSG and the ratio of GSH/GSSG in the CDH4 down-regulation experiment and CDH4 up-regulation experiment G-H. The MDA in the CDH4 down-regulation experiment and CDH4 up-regulation experiment (Fig. I-J). (* indicates P < 0.05, **indicates P < 0.01, ***indicates P < 0.001, ****indicates P < 0.0001, and Values are presented as means ± standard error.)