Table 2 Comparison of mean values of MMP-1, MMP-2, MMP-8, MMP-9, IL-1β, IL-8 in all samples with the control value
From: Effects of metformin on human gingival fibroblasts: an in vitro study
Outcome variables | Mean values using Metformin | Control value | Difference in mean value | t-value | p-value |
|---|---|---|---|---|---|
MMP-1 Sample2 Sample3 Sample4 Sample5 Sample6 Sample7 Sample8 Sample9 | 32919.67 32310.67 30370.66 31531.00 27479.00 28111.33 26674.33 30044.33 | 34154.33 34154.33 34154.33 34154.33 34154.33 34154.33 34154.33 34154.33 | -1234.66 -1843.66 -3783.66 -2623.33 -6675.33 -6042.99 -7479.99 -4109.99 | -0.609 -1.364 -3.771 -0.982 -7.028 -5.012 -17.462 -2.579 | 0.604 0.306 0.063 0.429 0.019* 0.037* 0.003* 0.123 |
MMP-2 Sample2 Sample3 Sample4 Sample5 Sample6 Sample7 Sample8 Sample9 | 85000.33 85175.66 86440.00 87454.66 42692.33 34762.00 43714.66 42102.00 | 85914.67 85914.67 85914.67 85914.67 85914.67 85914.67 85914.67 85914.67 | -914.33 -739.00 525.33 1539.99 -43222.33 -51152.67 -42200.00 -43812.67 | -0.494 -1.327 0.177 1.107 -158.551 -50.521 -54.857 -440.638 | 0.670 0.315 0.875 0.383 < 0.0001* < 0.0001* < 0.0001* < 0.0001* |
MMP-8 Sample2 Sample3 Sample4 Sample5 Sample6 Sample7 Sample8 Sample9 | 101.69 99.69 101.69 184.24 87.31 105.82 103.66 97.69 | 121.51 121.51 121.51 121.51 121.51 121.51 121.51 121.51 | -19.813 -21.816 -19.813 62.730 -34.193 -15.689 -17.843 -23.820 | -2.805 -4.019 -2.805 12.110 -16.256 -3.893 -2.4298 -11.619 | 0.107 0.056 0.107 0.006* 0.003* 0.060 0.135 0.007* |
MMP-9 Sample2 Sample3 Sample4 Sample5 Sample6 Sample7 Sample8 Sample9 | 74.90 67.80 62.99 59.60 66.39 73.20 68.09 66.05 | 69.79 69.79 69.79 69.79 69.79 69.79 69.79 69.79 | 5.11 -1.98 -6.80 -10.18 -3.40 3.41 -1.69 -3.73 | 1.730 -0.258 -2.000 -1.733 -1.000 0.999 -0.377 -1.150 | 0.225 0.820 0.183 0.225 0.422 0.422 0.742 0.369 |
IL-1 β Sample2 Sample3 Sample4 Sample5 Sample6 Sample7 Sample8 Sample9 | 13.74 15.03 14.62 14.62 15.04 13.52 13.07 13.44 | 15.18 15.18 15.18 15.18 15.18 15.18 15.18 15.18 | -1.43 -0.14 -0.56 -0.56 -0.13 -1.65 -2.10 -1.73 | -1.836 -0.193 -1.515 -1.515 -0.250 -1.907 -1.812 -1.906 | 0.207 0.864 0.268 0.268 0.8257 0.196 0.211 0.196 |
IL-8 Sample2 Sample3 Sample4 Sample5 Sample6 Sample7 Sample8 Sample9 | 6055.33 6094.66 6139.00 5990.66 5689.66 2952.00 4085.66 3885.00 | 6229.67 6229.67 6229.67 6229.67 6229.67 6229.67 6229.67 6229.67 | -174.33 -135.00 -90.67 -239.00 -540.00 -3277.67 -2144.00 -2344.67 | -1.460 -21.316 -0.900 -1.978 -7.914 -8.306 -11.37 -25.311 | 0.281 0.202 0.4627 0.186 0.015* 0.014* 0.008* 0.002* |