Table 1 Characteristics of the studies included in the quantitative assessment
Author and year | Study design | Number of patients | Test group | Control group | Follow-up time (months) | Membrane | Used tooth part | Defect morphology | Outcomes |
|---|---|---|---|---|---|---|---|---|---|
I. W. Um et al. 2019 [34] | case series | T: 10 C: 6 | DDM + rhBMP-2 | DDM | 3–6 | no | root | NA | ridge width changes (mm), histological outcomes (%) |
C. P. Joshi et al. 2016 [35] | randomized controlled trial | T1: 15 T2: 15 C: 15 | T1: ATG T2: β-TCP | ungrafted | 4 | yes | root and crown | min. 5 mm deep, 4 walled bony defects | ridge width changes (mm) |
A. Dwivedi et al. 2020 [36] | case series | 30 | ATG | NA | 4 | no | root and crown | NA | ridge width changes (mm) |
Z. Radoczy-Drajko et al. 2021 [37] | case series | 9 | ATB | NA | 6 | yes | root and crown | EDS3-4 | ridge width praeop-postop (mm), histological outcomes (%) |
A. Elfana et al. 2021 [38] | randomized controlled trial | T: 10 C: 10 | AWTG | ADDG | 6 | yes | root and crown | less than 5 mm buccal bony wall defect | ridge width changes (mm), histological outcomes (%) |
G. U. Jung et al. 2018 [39] | randomized controlled trial | T1: 8 T2: 8 C: 8 | T1: DDM T2: DDM + rhBMP-2 | Bio-Oss Collagen | 4 | yes | root | less than 50% buccal bony defect | ridge width praeop-postop (mm), histological outcomes (%) |
K. M. Pang et al. 2017 [40] | randomized controlled trial | T: 21 C: 12 | AutoBT | Bio-Oss | 6 | no | root and crown | min. 4 mm of vertical dimension loss in more than 1 wall | histological outcomes (%) |
A. Santos et al. 2021 [29] | randomized controlled trial | T: 34 C: 32 | MDM | Bio-Oss | 6 | yes | root and crown | Elian type II defects | histological outcomes (%) |