Metabolome and microbiome of chronic periapical periodontitis in permanent anterior teeth: a pilot study

BMC Oral Health

Table 2 Potential bio-markers of periapical lesions in anion mode

Name	VIP	P value	Potential Role	References
L-Phenylalanine	1.7786	6.02E−06	Inhibiting 5-phenylalanine decarboxylase	[17]
L-Glutamate	1.5181	0.000137	Increasing IFN-γ and IL-10	[18]
L-Tryptophan	1.5134	3.79E−06	Decreasing Il-1β, Il-6, IL-8, TNF-α	[19]
L-Alanine	1.4168	1.44E−05	Decreasing TNF-a	[20]
Glucosamine	1.3915	0.000693	anti-inflammary, antioxidant	[14, 19]
L-Serine	1.3393	4.59E−05	Regulating of T-cell Proliferation	[21]
L-Asparagine	1.2961	1.93E−05	Decreasing TNF-α and IL-1β	[22]
L-Valine	1.1814	2.12E−06	Generating immunoglobulin Decreasing TNF-α, IL-6, INF-γ, IL-1β and IL-17	[23]
Linoleic acid	1.1752	0.011785	No influence	[24]
Taurine	1.0241	0.013787	Decreasing TNF-α, IL-6 and Oxidative stress	[25]

ISSN: 1472-6831