An underestimated pitfall of oral candidiasis in head and neck cancer patients undergoing radiotherapy: an observation study

Table 6 Logistic regression of risk factors of clinical candidiasis throughout the treatment

Patient characteristics	Univariate		Multivariate
Patient characteristics	OR (95 %CI)	p value	OR (95 %CI)	p value
Sex		0.038*	10.93 (2.26–52.86)	0.003^#
Male	1
Female	2.71 (1.06–6.95)
Age	1.02 (0.98–1.07)	0.269
Underlying disease
DM	2.45 (0.39–15.52)	0.341
HT	1.27 (0.48–3.36)	0.629
Tumor site
Nasopharynx	1
Oropharynx	1.16 (0.38–3.55)	0.790
Oral cavity	3.05 (1.04-9.00)	0.043
Radiotherapy option
Postoperative RT
Radical RT	1 0.51 (0.20–1.29)	0.158*
Dose of radiotherapy (Gy)	0.90 (0.81–1.01)	0.066*
CCRT	1.72 (0.55–5.45)	0.354
CCRT cycle	0.34 (0.54–1.29)	0.419
Type of chemotherapy agent
Cisplatin	1
Carboplatin	0.63 (0.24–1.68)	0.357
Personal history
Smoking
Never used	1
Using currently	2.56 (0.83–7.85)
Alcohol
Never used	1	0.100*
Using currently	0.68 (0.28–1.67)	0.400	12.57 (2.19–72.29)	0.005^#
Oral status
Oral hygiene
Excellent/good	1
Fair/poor	0.57 (0.16–1.98)	0.373
Denture wearer	0.75 (0.17–3.23)	0.700
Mouthwash using
Non-benzydamine HCl	1
Benzydamine HCl	0.44 (0.15–1.28)	0.133*
2% viscous lidocaine solution using	2.03 (0.74–5.58)	0.172*
Xerostomia	2.03 (0.72–5.71)	0.180*
Mucositis	4.13 (1.60-10.69)	0.003*
Candida colonization before RT	2.13 (0.87–5.21)	0.100*

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