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Table 3 Radioactivity of 14C-lidocaine in the serum

From: Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats

 

Lidocaine

Mean ± SD

Lidocaine with epinephrine

Mean ± SD

p value

Sample size

12

12

 

Time (min)

   

 0.5

19.1 ± 9.2

15.6 ± 6.7

0.291

 2

21.8 ± 10.4

24.8 ± 5.6

0.383

 5

34.1 ± 9.5

30.7 ± 6.6

0.322

 10

55.9 ± 4.3

40.9 ± 4.8

< 0.001

 20

76.9 ± 8.2

48.4 ± 8.6

< 0.001

 30

63.4 ± 7.8

59.8 ± 4.7

0.189

 40

49.3 ± 5.7

70.2 ± 4.4

< 0.001

 50

34.8 ± 7.3

88.2 ± 2.9

< 0.001

 60

20.6 ± 9.5

81.0 ± 4.8

< 0.001

  1. Data presented as the mean of 14C radioactivity in dpm/1 mL serum
  2. p value compares lidocaine versus lidocaine with epinephrine
  3. Unpaired t-test used to compare means
  4. SD standard deviation