Fig. 3

The three‐dimensional images of micro-computed tomography reconstructed. We captured three-dimensional images of buccal sides (A, C, E) and palatal sides (B, D, F) of periodontal tissues. The bone volumes of mice in the periodontitis group (C, D) were markedly reduced, compared with those of mice in the control group (A, B). Notably, mice in the periodontitis + anti-G-CSF group showed significant attenuation of alveolar bone resorption (E, F), bone mass loss was also partially alleviated. Mice in the periodontitis + anti-G-CSF group also showed improvements in bone volume/total volume (G), bone surface area/bone volume (H), trabecular thickness (I), trabecular spacing (K), and trabecular pattern factor (L) values, compared with mice in the periodontitis group (P < 0.05). However, there were no differences in trabecular number values (J, P > 0.05). Data are shown as mean ± SD, *P < 0.05, **P < 0.01; ns, no differences. One-way ANOVA with Bonferroni correction