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Table 1 Clinical features and treatment regimens of MRONJ patients

From: Medication-related osteonecrosis of the jaw (MRONJ) and eNOS Polymorphisms in multiple myeloma patients: a single center experience

 

MRONJ patients

Controls

 

n:60 (%)

n:60 (%)

Age

53 (37–71)

54 (29–71)

Gender

 Females/males

31/29 (52/48)

29/31 (48/52)

Ig subtypes

 κ/λ

22/11 (64.9/35.1)

 

 G/A

23/5 (67.4/16)

 

 Light chain

5 (16.6)

 

Stage (Salmon–Durie)

 II/III

10/23 (31/69)

 

 A/B

27/6 (76/24)

 

IPI

 I

10 (30.2)

 

 II/III

9/13 (26.6/43.2)

 

ECOG

 > 1

4/33 (16.6)

 

Hemoglobin

 gr/dL

10.7 (6.6–14.7)

 

Leucocytes

 μL

6100(2760–17,300)

 

Platelets

 103/μL

198 (123–337)

 

C-reactive protein

 mg/dL

6.6 (2.1–215)

 

LDH

 IU/L

235 (100–556)

 

β2-microglobulin

 mg/L

4.7 (1.5–47)

 

Albumin

 g/L

3.6 (2.2–5.1)

 

Treatment

 VCD, ASCT, LD

60

 

OS % (5 years)

76

 

PFS (month)a

54.3

 

Follow up durationa (month)

36 (7.8–99.1)

 
  1. VCD, bortezomib, cyclophosphamide, dexamethasone; APBSCT: autologous peripheral blood stem cell transplantation LD, lenolidomid, dexamethasone; ECOG, performance status; LDH, lactic dehidrogenase; IPI, International Prognostic Index; PFS, progression-free survival, OS: Overall survival
  2. aMedian