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Table 1 General characteristics of selected studies

From: Effect of tetracyclines on pulpal and periodontal healing after tooth replantation: a systematic review of human and animal studies

Study ID

Subjects (n)

Teeth replanted (n) and the stage of root development

The status of root canal

Extra-alveolar time and storage conditions

Splinting or not

Duration of study

Cvek et al. [23]

Monkeys

(n = 32)

Immature, maxillary incisors (105 teeth)

Untreated

30 or 60 min, dry or wet

Splinting with a band of a composite material

6–8 weeks

Sae-Lim et al. [25]

Beagles (n = 5)

Mature, lateral incisors, first and third premolars (30 roots)

Root canals, infected by dental plaque

less than 5 min

Splinting with resorbable sling sutures

5–6 months

Sae-Lim et al. [26]

Beagles (n = 4)

Mature, lateral incisors, the first and third premolars (31 roots)

Endodontic treatment

60 min, dry

Splinting with resorbable sling sutures

12 weeks

Cvek et al. [24]

Monkeys

(n = 47)

Immature, maxillary incisors (171 teeth)

Untreated

30 or 60 min, dry or wet

Splinting whit a band of a composite material

6–8 weeks

Yanpiset et al. [29]

Mongrel dogs (n = 4)

Immature, 48 incisors and 48 premolars

Untreated

5 min, dry

No fixation

3 months

Ma et al. [27]

Monkeys

(n = 7)

Mature, incisors and mandibular posterior teeth (32 roots)

Endodontically treated

60 min, dry

No fixation

12 weeks

Ritter et al. [28]

Mongrel dogs (n = 3)

Immature, 22 incisors and 12 premolars

Untreated

5 min, dry

No fixation

60 days

Bryson et al. [34]

Mongrel dogs (n = 4)

Mature, premolar roots (69 roots)

Endodontically treated

60 min, dry

No splinting

4 months

Chen et al. [21]

Beagles (n = 3)

Mature, premolar roots (24 roots)

Endodontically treated

60 min, dry

No splinting

4 months

Gomes et al. [32]

Wistar Rats (= 60)

Maxillary right incisor (n = 60)

Endodontically treated

60 min, dry

No splinting

7, 15, and 30 days after replantation

Melo et al. [33]

Wistar Rats (n = 60)

Maxillary right incisor (n = 60)

Untreated

5 min, immersed in saline

No splinting

7, 15, and 30 days after replantation

Bjorvatn et al. [36]

Beagles (n = 5)

Mature, mandibular incisors (n = 9)

Untreated

45 min, dry

Non-rigid splinting with dental floss

4 weeks after replantation

Selvig et al. [35]

Beagles (n = 5)

Mature, mandibular incisors( n = 10)

The middle part of the root was then root-planed extensively, leaving the cervical and apical root surface areas uninstrumented

45 min, dry

No fixation

21 days after replantation

Liu et al. [50]

Human

(n = 38)

Mature and immature teeth, (n = 44)

Immature teeth were replanted without endodontic treatment, and endodontic treatment was indicated for those mature teeth with extra-oral time longer than 2 h before replantation

Extra-alveolar time and storage conditions varied in different cases

Splinting with composite resin

About 28 months after replantation

Nam et al. [51]

Sprague–Dawley rats

(n = 20)

maxillary first molars with complete root formation (n = 40)

Untreated

dry for 5 min or 60 min in Hank's balanced salt solution (HBSS)

No splinting

8 weeks after replantation