Table 4 Results of the included studies
Study | Intervention and Comparator | Outcome Measure | Summary Intervention | Summary Comparator |
|---|---|---|---|---|
Karched et al., 2019 | -38% SDF vs. -SDF/KI vs. -2%CHX (+ve control) | -Total viable count--Colony forming units | Median CFU counts/mg of dentine following SDF/KI treatment 9x105 to 1.6x 102 | Median CFU counts/mg of dentine after CHX treatment 1.6x103 to 1.1x 102 |
Milgrom et al., 2018 | -38% SDF vs. -placebo blue tinted distilled water | -RNA sequencing analysis to identify relative abundance of caries-associated microbes | RNA sequencing analysis identified no consistent changes in the relative abundance of cariogenic microbes | Â |
Mitwalli et al., 2019 | -38% Silver diamine fluoride | -16S rDNA sequencing to determine bacterial profiles | Decrease in count of acidogenic bacterial species post-SDF treatment Actinomyces sp. HOT448 Propionibacterium acidifaciens Scardovia inopinata Propionibacterium sp. HOT194 Treponema denticola Bifidobacterium dentium Propionibacterium genus probe Parascardovia denticolens Scardovia genus probe 4 Actinomyces israelii | Â |
Mei et al., 2013 | -38% SDF vs. -Distilled water | -Microbial Kinetics-Colony forming units -Viability of microbes-Confocal microscopy | Day 21 (total bacteria) 5.72±0.19 Day 21Dead: live ratio 0.92±0.36 | Day 21 (total bacteria) 12.20±0.84 Day 21Dead: live ratio 0.004±0.001 |
Chu et al., 2012 | -38% SDF vs. -Distilled water | -Microbial Kinetics-Colony forming units -Viability of microbes-Confocal microscopy | S. mutans(Log CFU=0) A. naeslundii (Log CFU=0) S. mutansDead: live ratio 5.61±2.42 A. naeslundiiDead: live ratio 16.01±10.83 | S. mutans (Log CFU=6.03±0.18) A. naeslundii (Log CFU=7.00±0.24) S. mutansDead: live ratio 0.025±0.01 A. naeslundiiDead: live ratio 0.23±0.09 |
Mei et al., 2013(a) | -38% SDF vs. -Distilled water | -Microbial Kinetics-Colony forming units -Viability of microbes-Confocal microscopy | S. mutans(Log CFU=4.02±0.35) L.acidophilus (Log CFU=1.80±0.28) S.mutans and L. acidophilus Dead: live ratio 6.74±5.29 | S. mutans (Log CFU=6.03±0.18) L.acidophilus (Log CFU=7.00±0.24) S.mutans and L. acidophilus Dead: live ratio 0.02±0.002 |
Hamama et al., 2015 | -SDF/KI vs. -Chlorhexidine | -Mean percentages of dead and live bacteriaafter 5 minutes of surface treatment | SDF/KI group (56.1 ±13.0%) SDF/KI following Carisolv (27.7 ±13.5%) SDF/KI following Papacarie gel (36.9 ±4.4%) SDF/KI group (56.1 ±13.0%) | Carisolv (0.4± 0.7%) Papacarie (19.5± 6.6%) CHX (19± 10.8%) CHX vs. Papacarie gel (19.5± 6.6%) |
Besinis et al., 2014 | -Nanosilver (AgNPs) vs. -Silver nitrate (AgNO3) vs. -Chlorhexidine | - Measuring turbidity, -Proportion of live and dead cells and -lactate production | All three bioassays demonstrated both silver nanoparticles and silver nitrate dentine coatings highly bactericidal (>99.5%) against S. mutans | Chlorhexidine coating on dentine disc showed no antibacterial effect against S. mutans |