2007 | 2007–2015 | April-October 2015 | October 2015-February 2016 | December 2015-January 2016 |
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First diagnosis of GPA diagnosed by glomerulon ephritis | Permanent medication with prednisolone and cyclosporine. Development of a steroid-associated osteoporosis treated intravenously with denosumad. Over the time developing pulmonary emphysema, Raynaud’s phenomenon, sinusitis maxilliaris and orbital pseudotumor. | Development of gingival hyperlpasia. In the following periodontal theraphy without benefit by her dentist. Thus reffered to periodontist. Recommendation for gingivectomy, transfer to Department of Cranio-Maxillofacial Surgery, University Hospital Münster. Biospsy from hyperplastic gingivitis taken | Ambulant follow-up in the Department of Cranio-Maxillofacial Surgery, University Hospital Münster. | Suspiction of recurrence of GPA by increasing (c)-ANCA and clinical signs of recurrence. Stationary therapie at Internal Medicine Clinic, University Hospital Münster. In the following 375 mg/m2 rituximab weekly for a total of 4 doses, and prednisolone 10 mg/day. |