Statin use is associated with fewer periodontal lesions: A retrospective study

BMC Oral Health

Table 2 Statin medication and periodontal inflammatory injury.

	Non-users n = 76	Statin users n = 21	Difference (% of control)	95% CI (difference of means)	P-value*
A. Inflammatory burden^†
PPD^‡ ≥ 4 mm	79.1(3.7)	50.1 (7.0)	29.0 (-37%)	12.9 – 45.0	0.00043
4 mm ≤ PPD < 6 mm	50.7 (2.5)	36.0 (5.0)	14.7 (-29%)	3.2 – 26.2	0.0087
PPD ≥ 6 mm	20^§	11^§	11^\|\| (-55%)	4 – 20^¶	0.0010**
PIBI^††	107.6 (5.8)	64.3 (10.0)	43.1 (-40%)	19.5 – 66.7	0.00069
B. Tooth- adjusted inflammatory injury ^‡‡
PPD ≥ 4 mm	3.1 (0.14)	2. 1 (0.30)	0.98 (-32%)	0.28 – 1.61	0.0025
4 mm ≤ PPD < 6 mm	2.0 (0.10)	1.5 (0.20)	0.48 (-25%)	0.02 – 0.93	0.0274
PPD ≥ 6 mm	0.7^§	0.4^§	0.42^\|\| (-56%)	0.14 – 0.76^¶	0.0025**
PIBI	4.1 (0.22)	2.7 (0.44)	1.41 (-34%)	0.41 – 2.42	0.0033

* Two-tailed P-values. ^†Number of periodontal pockets, mean (SE), unless otherwise indicated. ^‡PPD is periodontal probing pocket depth. ^§Median. ^||Estimate for difference of population medians calculated as described by Campbell and Gardner [22]. ^¶Approximate 95% confidence interval (CI) for the difference in population medians calculated as described by Campbell and Gardner [22]. **P-value by Mann-Whitney U-test. ^††PIBI is Periodontal Inflammatory Burden Index. ^‡‡Number of periodontal pockets divided by number of teeth, mean (SE), unless otherwise indicated.

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