Table 3 Adjusted mean change from baseline in DHEQ Section 2 scores: Total score (Q1–34), Restrictions (Q1–4), Adaptation (Q5–16), Social Impact (Q17–21), Emotional Impact (Q22–29), Identity (Q30–34), Global Oral Health rating (Q35), Effect on Life Overall (Q36–39) at each time point compared to baseline (mITT population)

Week 4

1.18 (0.108, 2.262) 0.0312

1.11 (−1.592, 3.821) 0.4185

0.57 (−0.604, 1.738) 0.3415

2.42 (0.483, 4.352) 0.0145

Week 8

2.08 (1.728, 3.866) < 0.0001

7.08 (4.391, 9.764) < 0.0001

1.77 (0.610, 2.935) 0.0029

4.42 (2.498, 6.339) < 0.0001

Week 12

3.26 (2.192, 4.322) < 0.0001

8.35 (5.674, 11.026) < 0.0001

2.42 (1.266, 3.582) < 0.0001

6.85 (4.933, 8.759) < 0.0001

Week 16

3.93 (2.844, 5.012) < 0.0001

10.43 (7.708, 13.158) < 0.0001

3.55 (2.371, 4.729) < 0.0001

7.17 (5.219, 9.115) < 0.0001

Week 20

4.15 (3.063, 5.232) < 0.0001

11.73 (9.008, 14.459) < 0.0001

4.39 (3.210, 5.568) < 0.0001

8.39 (6.438, 10.335) < 0.0001

Week 24

4.74 (3.654, 5.823) < 0.0001

11.96 (9.235, 14.686) < 0.0001

4.30 (3.119, 5.477) < 0.0001

8.67 (6.726, 10.623) < 0.0001

Identity

Global Oral Health Rating

Effect on Life Overall

Week 4

0.63 (−0.738, 1.989) 0.3676

0.09 (−0.059, 0.243) 0.2326

0.60 (0.002, 1.194) 0.0493

Week 8

0.90 (−0.451, 2.255) 0.1907

0.07 (−0.085, 0.216) 0.3934

1.42 (0.830, 2.013) < 0.0001

Week 12

1.81 (0.467, 3.162) 0.0085

0.13 (−0.016, 0.284) 0.0785

1.87 (1.278, 2.457) < 0.0001

Week 16

2.12 (0.744, 3.489) 0.0026

0.14 (−0.011, 0.294) 0.0682

2.03 1.429, 2.629) < 0.0001

Week 20

2.74 (1.371, 4.116) 0.0001

0.13 (−0.018, 0.287) 0.0844

2.34 (1.743, 2.943) < 0.0001

Week 24

2.85 (1.477, 4.222) < 0.0001

0.18 (0.027, 0.332) 0.0211

2.34 (1.743, 2.943) < 0.0001