Biomarkera | Diagnosis (source) | p + (TIME) | Pain intensity | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MP (n = 6*) | DD(n = 6*) | Low (n = 6**) | High (n = 6**) | INTERACTION | ||||||||||
Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | Mean | (95% CI) | p+ (TIME) | p+ (TIME*SOURCE) | p+ (TIME*INTENSITY) | ||||
Morning | TAC | T0 | 0.62 | 0.25–0.99 | 0.50 | 0.13–0.87 | 0.074 | 0.40 | 0.19–0.61 | 0.72 | 0.31–1.13 | 0.076 | 0.48 | 0.91 |
T1 | 0.48 | 0.24–0.71 | 0.49 | 0.10–0.87 | 0.33 | 0.08–0.57 | 0.63 | 0.35–0.92 | ||||||
T2 | 0.37 | 0.04–0.70 | 0.34 | −0.05-0.74 | 0.22 | −0.02-0.48 | 0.48 | 0.09–0.48 | ||||||
MDA | T0 | 2.37 | 1.69–3.05 | 2.23 | 1.73–2.73 | 0.15 | 2.09 | 1.54–2.65 | 2.50 | 1.94–3.06 | 0.21 | 0.14 | 0.33 | |
T1 | 1.57 | 0.88–2.25 | 2.07 | 1.33–2.82 | 1.75 | 1.13–2.37 | 1.89 | 1.01–2.78 | ||||||
T2 | 1.81 | 1.27–2.34 | 2.28 | 1.75–2.81 | 2.07 | 1.61–2.53 | 2.01 | 1.31–2.71 | ||||||
SOD | T0 | 3.42 | 2.92–3.91 | 3.60 | 3.28–3.93 | 0.51 | 3.43 | 2.99–3.87 | 3.58 | 3.17–4.01 | 0.53 | 0.63 | 0.78 | |
T1 | 3.44 | 3.15–3.73 | 3.48 | 3.16–3.81 | 3.35 | 3.12–3.58 | 3.58 | 3.25–3.90 | ||||||
T2 | 3.40 | 3.03–3.77 | 3.39 | 3.07–3.71 | 3.31 | 3.10–3.52 | 3.48 | 3.06–3.91 | ||||||
UA | T0 | 2.74 | 2.37–3.11 | 2.60 | 2.22–2.98 | 0.17 | 2.53 | 2.37–2.69 | 2.81 | 2.34–3.27 | 0.19 | 0.35 | 0.98 | |
T1 | 2.60 | 2.43–2.78 | 2.64 | 2.20–3.08 | 2.49 | 2.22–2.76 | 2.75 | 2.42–3.08 | ||||||
T2 | 2.50 | 1.96–3.03 | 2.49 | 1.92–3.07 | 2.35 | 1.97–2.73 | 2.64 | 2.01–3.29 | ||||||
SC | T0 | 1.17 | 1.06–1.29 | 0.82 | 0.66–0.98 | 0.50 | 1.02 | 0.78–1.26 | 0.97 | 0.72–1.23 | 0.49 | 0.10 | 0.73 | |
T1 | 1.02 | 0.78–1.24 | 0.82 | 0.69–0.95 | 0.95 | 0.71–1.19 | 0.88 | 0.70–1.07 | ||||||
T2 | 1.05 | 0.84–1.26 | 1.00 | 0.66–1.33 | 0.99 | 0.72–1.26 | 1.06 | 0.77–1.34 | ||||||
Afternoon | TAC | T0 | 0.60 | 0.34–0.86 | 0.58 | 0.39–0.77 | 0.036* | 0.48 | 0.38–0.57 | 0.71 | 0.46–0.95 | 0.045* | 0.17 | 0.50 |
T1 | 0.50 | 0.26–0.74 | 0.47 | 0.10–0.84 | 0.43 | 0.22–0.63 | 0.54 | 0.17–0.92 | ||||||
T2 | 0.35 | 0.24–0.46 | 0.51 | 0.31–0.71 | 0.37 | 0.23–0.51 | 0.49 | 0.29–0.69 | ||||||
MDA | T0 | 2.76 | 2.39–3.13 | 2.55 | 1.81–3.30 | 0.52 | 2.47 | 1.87–3.07 | 2.84 | 2.31–3.36 | 0.38 | 0.43 | 0.02* | |
T1 | 2.34 | 1.58–3.10 | 2.69 | 1.87–3.51 | 2.86 | 2.18–3.54 | 2.17 | 1.42–2.92 | ||||||
T2 | 2.31 | 1.63–2.98 | 2.53 | 1.82–3.24 | 2.62 | 2.49–2.75 | 2.21 | 1.28–3.14 | ||||||
SOD | T0 | 3.31 | 2.85–3.76 | 3.52 | 3.28–3.77 | 0.23 | 3.40 | 3.01–3.80 | 3.43 | 3.06–3.80 | 0.22 | 0.88 | 0.78 | |
T1 | 3.23 | 2.72–3.74 | 3.41 | 3.24–3.58 | 3.27 | 2.81–3.73 | 3.37 | 3.06–3.68 | ||||||
T2 | 3.29 | 3.03–3.55 | 3.54 | 3.38–3.71 | 3.41 | 3.13–3.68 | 3.43 | 3.18–3.67 | ||||||
UA | T0 | 2.69 | 2.31–3.07 | 2.70 | 2.52–2.88 | 0.39 | 2.56 | 2.34–2.78 | 2.83 | 2.55–3.11 | 0.30 | 0.76 | 0.03* | |
T1 | 2.68 | 2.37–2.99 | 2.74 | 2.51–2.97 | 2.69 | 2.45–2.92 | 2.73 | 2.43–3.04 | ||||||
T2 | 2.56 | 2.19–2.93 | 2.67 | 2.33–3.01 | 2.51 | 2.23–2.77 | 2.73 | 2.34–3.12 | ||||||
SC | T0 | 0.50 | 0.19–0.80 | 0.28 | 0.04–0.60 | 0.99 | 0.50 | 0.20–0.80 | 0.28 | 0.04–0.60 | 0.99 | 0.24 | 0.04* | |
T1 | 0.45 | 0.07–0.82 | 0.33 | 0.11–0.55 | 0.41 | 0.15–0.69 | 0.35 | 0.01–0.70 | ||||||
T2 | 1.57 | 0.17–0.98 | 0.21 | 0.05–0.38 | 0.30 | 0.08–0.53 | 0.48 | 0.03–0.93 |