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Table 3 Statistical analysis of change from baseline in Schiff sensitivity score and tactile threshold (intent-to-treat population)

From: Randomised clinical studies investigating immediate and short-term efficacy of an occluding toothpaste in providing dentine hypersensitivity relief

 

Test*

Control*

Test vs Cont**

Schiff sensitivity score

Study 1

BL

2.53 (0.035)

2.55 (0.036)

 

0 d

−0.46 (− 0.55, − 0.38) p < 0.0001

−0.45 (− 0.53, − 0.37) p < 0.0001

−0.01 (− 0.131, 0.102) p = 0.8067

3 d

−0.83 (− 0.92, − 0.74) p < 0.0001

−0.38 (− 0.47, − 0.29) p < 0.0001

−0.45 (− 0.577, − 0.319) p < 0.0001

Study 2

BL

2.5 (0.046)

2.46 (0.044)

 

0 d

−0.17 (− 0.23, − 0.11) p < 0.0001

−0.02 (− 0.08, 0.04) p = 0.5089

−0.15 (− 0.232, − 0.070) p = 0.0003

3 d

−0.40 (− 0.47, − 0.33) p < 0.0001

0.00 (− 0.07, 0.08) p = 0.9298

−0.40 (− 0.505, − 0.300) p < 0.0001

Study 3

BL

2.44 (0.046)

2.49 (0.049)

 

0 d

−0.69 (− 0.80, − 0.57) p < 0.0001

−0.09 (− 0.20, 0.03) p = 0.1281

−0.60 (− 0.759, − 0.435) p < 0.0001

3 d

−1.44 (−1.57, −1.31) p < 0.0001

−0.13 (− 0.26, 0.01) p = 0.0630

−1.31 (− 1.500, − 1.128) p < 0.0001

Tactile threshold

Study 1

BL

10.00 (0.000)

10.00 (0.000)

 

0 d

+4.00 (2.68, 5.31) p < 0.0001

+ 3.60 (2.29, 4.92) p < 0.0001

0.39 (−1.465, 2.253) p = 0.6770

3 d

+ 15.22 (12.83, 17.61) p < 0.0001

+ 3.92 (1.55, 6.29) p = 0.0013

11.30 (7.937, 14.662) p < 0.0001

Study 2

BL

12.66 (0.399)

13.42 (0.405)

 

0 d

+ 1.67 (1.14, 2.19) p < 0.0001

+ 0.23 (−0.30, 0.75) p = 0.4001

1.44 (0.694, 2.188) p = 0.0002

3 d

+ 3.68 (2.94, 4.41) p < 0.0001

+ 0.11 (−0.63, 0.84) p = 0.7775

3.57 (2.531, 4.614) p < 0.0001

Study 3

BL

13.40 (0.431)

13.58 (0.453)

 

0 d

+ 9.05 (7.25, 10.85) p < 0.0001

+ 1.07 (−0.75, 2.89) p = 0.2461

7.98 (5.423, 10.539) p < 0.0001

3 d

+ 25.87 (22.92, 28.82) p < 0.0001

+ 1.32 (−1.66, 4.30) p = 0.3816

24.54 (20.349, 28.736) p < 0.0001

  1. Baseline values are raw means (standard error), and only include participants with a corresponding post-baseline assessment, for post-baseline visit output is obtained from ANCOVA model
  2. *Change from baseline (95% CI) p-value
  3. **Difference (95% CI) p-value: first-named minus second-named group such that, for Schiff sensitivity score, a negative difference favours the first-named group or, for tactile threshold, a positive difference favours the first-named group
  4. BL: Baseline; d: day
  5. P-values in bold are below the p=0.05 threshold