| Test* | Control* | Test vs Cont** | |
---|---|---|---|---|
Schiff sensitivity score | ||||
Study 1 | BL | 2.53 (0.035) | 2.55 (0.036) | Â |
0 d | −0.46 (− 0.55, − 0.38) p < 0.0001 | −0.45 (− 0.53, − 0.37) p < 0.0001 | −0.01 (− 0.131, 0.102) p = 0.8067 | |
3 d | −0.83 (− 0.92, − 0.74) p < 0.0001 | −0.38 (− 0.47, − 0.29) p < 0.0001 | −0.45 (− 0.577, − 0.319) p < 0.0001 | |
Study 2 | BL | 2.5 (0.046) | 2.46 (0.044) | Â |
0 d | −0.17 (− 0.23, − 0.11) p < 0.0001 | −0.02 (− 0.08, 0.04) p = 0.5089 | −0.15 (− 0.232, − 0.070) p = 0.0003 | |
3 d | −0.40 (− 0.47, − 0.33) p < 0.0001 | 0.00 (− 0.07, 0.08) p = 0.9298 | −0.40 (− 0.505, − 0.300) p < 0.0001 | |
Study 3 | BL | 2.44 (0.046) | 2.49 (0.049) | Â |
0 d | −0.69 (− 0.80, − 0.57) p < 0.0001 | −0.09 (− 0.20, 0.03) p = 0.1281 | −0.60 (− 0.759, − 0.435) p < 0.0001 | |
3 d | −1.44 (−1.57, −1.31) p < 0.0001 | −0.13 (− 0.26, 0.01) p = 0.0630 | −1.31 (− 1.500, − 1.128) p < 0.0001 | |
Tactile threshold | ||||
Study 1 | BL | 10.00 (0.000) | 10.00 (0.000) | Â |
0 d | +4.00 (2.68, 5.31) p < 0.0001 | + 3.60 (2.29, 4.92) p < 0.0001 | 0.39 (−1.465, 2.253) p = 0.6770 | |
3 d | + 15.22 (12.83, 17.61) p < 0.0001 | + 3.92 (1.55, 6.29) p = 0.0013 | 11.30 (7.937, 14.662) p < 0.0001 | |
Study 2 | BL | 12.66 (0.399) | 13.42 (0.405) | Â |
0 d | + 1.67 (1.14, 2.19) p < 0.0001 | + 0.23 (−0.30, 0.75) p = 0.4001 | 1.44 (0.694, 2.188) p = 0.0002 | |
3 d | + 3.68 (2.94, 4.41) p < 0.0001 | + 0.11 (−0.63, 0.84) p = 0.7775 | 3.57 (2.531, 4.614) p < 0.0001 | |
Study 3 | BL | 13.40 (0.431) | 13.58 (0.453) | Â |
0 d | + 9.05 (7.25, 10.85) p < 0.0001 | + 1.07 (−0.75, 2.89) p = 0.2461 | 7.98 (5.423, 10.539) p < 0.0001 | |
3 d | + 25.87 (22.92, 28.82) p < 0.0001 | + 1.32 (−1.66, 4.30) p = 0.3816 | 24.54 (20.349, 28.736) p < 0.0001 |