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Table 1 Major and minor diagnostic criteria of NBO

From: Chronic recurrent multifocal osteomyelitis in association with pyoderma gangraenosum

Major diagnostic criteria

Minor diagnostic criteria

Radiologically proven osteolytic/-sclerotic bone lesion

Normal blood count and good general state of health

Multifocal bone lesions

CRP and ESR mildly-to-moderately elevated

PPP or psoriasis

Observation time longer than 6 months

Sterile bone biopsy with signs of inflammation and/or fibrosis, sclerosis

Hyperostosis

Associated with other autoimmune diseases apart from PPP or psoriasis

Grade I or II relatives with autoimmune or autoinflammatory disease, or with NBO