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Table 1 Inclusion and Exclusion criteria

From: Is there a place for Tooth Mousse® in the prevention and treatment of early dental caries? A systematic review

Inclusion criteria

Exclusion criteria

Participants: People of any age or gender at risk of dental caries.

Reviews, case reports, abstracts, letters to editors, editorials, commentaries, in vitro and in situ studies utilising bovine or human enamel were excluded.

Interventions: The use of Tooth Mousse® (MI Paste®) or Tooth Mousse Plus® (MI Paste Plus®) in accordance with the manufacturer’s instructions for the prevention or treatment of dental caries.

Non-english language studies were excluded.

Comparisons: Tooth Mousse® (MI Paste®) or Tooth Mousse Plus® (MI Paste Plus®) (Test) versus a routine oral care regimen for the prevention of dental caries (Control) with or without comparisons to additional preventive products.

Studies utilising an artificial caries model or enamel demineralization model were excluded.

Outcomes: Recognised clinical measures of early caries lesions or enamel demineralisation including - enamel microhardness, DIAGNOdent readings, QLF measurements, clinical caries scoring and visual inspection of photographic images.

Interventions: Only Tooth Mousse® (MI Paste®) or Tooth Mousse Plus® (MI Paste Plus®) formulations were considered. No other formulations of CPP-ACP such as gum, lozenges, solutions, mouthrinses, toothpastes or varnishes were considered.

Study Design: Clinical trials

Studies in which Tooth Mousse® (MI Paste®) or Tooth Mousse Plus® (MI Paste Plus®) was not used in accordance with the manufacturer’s directions for use were excluded.