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Table 2 The pathway enrichment analysis of the DEGs

From: Genes related to inflammation and bone loss process in periodontitis suggested by bioinformatics methods

KEGG ID

Name

Count

p-value

A: the top 10 enriched pathways of the up-regulated DEGs

5150

Staphylococcus aureus infection

55

4.40E-12

5144

Malaria

51

2.12E-09

4060

Cytokine-cytokine receptor interaction

265

2.39E-08

4141

Protein processing in endoplasmic reticulum

165

5.11E-07

4640

Hematopoietic cell lineage

88

5.53E-07

5323

Rheumatoid arthritis

91

8.66E-07

5140

Leishmaniasis

72

1.64E-06

4670

Leukocyte transendothelial migration

116

4.30E-06

4514

Cell adhesion molecules (CAMs)

133

6.18E-06

4062

Chemokine signaling pathway

189

1.71E-05

B: the top 10 enriched pathways of the down-regulated DEGs

590

Arachidonic acid metabolism

59

0.002776062

980

Metabolism of xenobiotics by cytochrome P450

71

0.005420335

982

Drug metabolism - cytochrome P450

73

0.005982341

350

Tyrosine metabolism

41

0.007842248

1100

Metabolic pathways

1130

0.012102847

5144

Malaria

51

0.014274311

5014

Amyotrophic lateral sclerosis (ALS)

53

0.015832167

4145

Phagosome

153

0.018215247

4916

Melanogenesis

101

0.018240082

563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

25

0.025692313

830

Retinol metabolism

64

0.026060907

591

Linoleic acid metabolism

30

0.036083866